The porphyrins of acute porphyria. The detection of hitherto unrecognized porphyrins
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چکیده
منابع مشابه
The porphyrins of acute porphyria. The detection of hitherto unrecognized porphyrins.
Waldenstr6m (1934) reported the natural occurrence inacute porphyria ofauroporphyrinIII, butWatson, Schwartz & Hawkinson (1945) and Prunty (1946) found evidence for the belief that this Waldenstr8m porphyrin was a mixture of a large proportion of uroporphyrin I with a smaller amount of a type III porphyrin. The observations of Watson et al. (1945) also indicated the presence in the urine ofporp...
متن کاملThe Excretion of Porphyrins in Congenital Porphyria.
In 1915 Hans Fischer identified the kinds and types of porphyrins excreted in congenital porphyria (1, 2, 3), and since that time 8 cases of this rare disease have been studied by qualitative, chemical methods (4 to 11). No quantitative studies of the total excretion of porphyrins in this condition have been made, however, and although reports of the therapeutic effect of liver extract on acute...
متن کاملHepta-, hexa-, and pentacarboxylic porphyrins of porphyria cutanea tarda. II. Preparation of the porphyrins by stepwise decarboxylation ofuroporphyrins.
Hepta-, hexa-, and pentacarboxylic porphyrins have been detected in porphyric as well as normal urine samples. From the former they have been isolated and converted into pure methyl esters (1). For a better understanding of the chemistry of these porphyrins, pure uroporphyrin I and uroporphyrin III were separately subjected to decarboxylation under controlled conditions. The decarboxylation pro...
متن کاملThin-layer chromatography of free porphyrins for diagnosis of porphyria.
In this simple thin-layer chromatographic (TLC) technique for evaluating porphyrin excretion, porphyrins are extracted from urine or feces, then separated on silica-gel TLC plates. The distinct porphyrin bands are observed by viewing the plates under long-wave fluorescent light. Positive screening tests can readily be confirmed or rejected, and a more comprehensive investigation confidently und...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1950
ISSN: 0306-3283
DOI: 10.1042/bj0460147